345models & resources
203open code + weights
100gated / hub weights
20web / API only
10categories
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⚡ Quick chooser — pick by task
| Protein embeddings | ESM-C, ESM-2, ProtTrans, Ankh, SaProt, AMPLIFY |
| Protein variant effect / fitness | ESM-1v, Tranception, EVE, PoET, ProteinNPT, Protriever |
| Protein structure from sequence | ESMFold, AlphaFold2, OpenFold, OmegaFold |
| Protein / binder design | ProteinMPNN, LigandMPNN, RFdiffusion, RFdiffusion2, Chai-2 |
| De novo protein generation | ESM3, ProGen2, Chroma, DPLM, EvoDiff, Genie 2 |
| Antibody modeling | IgLM, AntiBERTy, AbLang, BALM, p-IgGen, IgFold, AntiFold |
| Long genomic DNA modeling | HyenaDNA, Caduceus, Nucleotide Transformer, Evo 2 |
| Regulatory genomics / variant effect | Enformer, Borzoi, AlphaGenome, Sei, Evo 2, GPN-MSA |
| RNA sequence / function | RNA-FM, RiNALMo, ERNIE-RNA, Orthrus, UTR-LM |
| RNA structure (3D) | RhoFold+, trRosettaRNA, DRfold, RoseTTAFoldNA |
| Single-cell embeddings | Geneformer, scGPT, scFoundation, UCE, scPRINT, SCimilarity |
| Perturbation / virtual cell | scGPT, STATE, Tahoe-x1, scFoundation |
| Pathology / histology (WSI) | UNI, Virchow, CONCH, H-optimus, Prov-GigaPath, TITAN |
| Spatial transcriptomics | Nicheformer, scGPT-spatial |
| Cell imaging / morphology | OpenPhenom, SubCell, Cell-DINO |
| Molecular property / embeddings | MoLFormer, Uni-Mol, ChemBERTa, MolCLR, Uni-Mol2 |
| Molecular generation | GenMol, SAFE-GPT, MolGPT, MegaMolBART, Megalodon |
| Biomolecular complexes | AlphaFold 3, Chai-1, Boltz, Protenix, RoseTTAFold-AA, HelixFold3 |
| Protein-ligand docking | DiffDock, DiffDock-L, Uni-Mol Docking V2, Umol, FlowDock |
| Unified access layer | Helical, CZI Virtual Cells, NVIDIA BioNeMo, AIDO |
| Benchmarks to evaluate on | ProteinGym, BEND, scEval, TDC, Open Problems |
| Input → Output | Use cases | Links |
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